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Role of Small Gauge Proportionate Reflux (SGPR) assisted hydro-dissection in elevated symptomatic Vitreo Foveal Traction (VFT).

To describe a new technique to release the elevated symptomatic Vitreo-Foveal Traction (VFT).

This was a retrospective, interventional case series where a new technique of hydro-dissection by Proportionate Reflux (PR) property of small gauge vitrectomy cutter was used in cases of elevated symptomatic VFT as evident on Optical Coherence Tomography. After vitrectomy, an opening was made in the taut posterior hyaloid face around the foveal elevation. Then the cutter tip was insinuated inside the hyaloid opening and the port opening was directed towards the tip of the fovea at its hyaloid attachment. The PR property of the cutter was then used to cause reflux of cassette fluid. The hydrostatic force thus generated separates the vitreofoveal attachment. End point was separation of VFT.

Seven eyes of seven patients were operated by 27-Gauge (n=3) or 25-Gauge (n=4) vitrectomy system. Mean pre-operative and post-operative BCVA were LogMAR 0.44 (20/55) ± 0.14 and LogMAR 0.27 (20/37) ± 0.11 respectively (p=0.23). Mean pre-operative foveal elevation was 560.86 ± 196.57 micron, which significantly decreased post-operatively to 251 ± 79.13 micron (p<0.01). VMTs were successfully released in all cases. Mean follow up was 184.00±80.32 days.

Small gauge PR assisted hydro-dissection is an innovative technique for management of elevated symptomatic cases of VFT.

Small gauge PR assisted hydro-dissection is an innovative technique for management of elevated symptomatic cases of VFT.

To compare changes of chorioretinal blood perfusion between Bietti crystalline dystrophy (BCD) and typical retinitis pigmentosa (RP) and perform a staging and a longitudinal analysis of chorioretinal perfusion in BCD.

Twenty-eight BCD patients (56 eyes), 28 typical RP patients (56 eyes), and 28 healthy subjects (56 eyes) were enrolled. Macular structural parameters and subfoveal choroidal thickness were measured via optical coherence tomography. Retinal vessel and perfusion densities were calculated using optical coherence tomography angiography. Choroidal blood perfusion was assessed through indocyanine-green angiography. Results of the BCD group were compared to those of the RP and control groups and followed by a staging and a longitudinal analysis of BCD.

Macular structural and perfusion parameters were decreased less in the BCD group than those in the RP group. Subfoveal choroidal thickness was significantly thinner in the BCD group, with a remarkable choroidal perfusion deficit using indocyanine-green angiography. The staging analysis revealed damage of both retinal and choroidal perfusion in BCD, however, the longitudinal analysis showed the impairment of choroidal perfusion outweighed retinal.

Both retinal and choroidal blood perfusion are impaired in BCD, but choroidal perfusion deficit caused by CYP4V2 mutations may play a more vital pathologic role.

Both retinal and choroidal blood perfusion are impaired in BCD, but choroidal perfusion deficit caused by CYP4V2 mutations may play a more vital pathologic role.

Stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) is a disorder characterized by splitting of the retina at the macula, without a known underlying mechanical or inherited cause. This study investigates demographic, anatomical and functional characteristics of subjects with SNIFR, to explore potential underlying mechanisms.

In this single-site, retrospective and cross-sectional, observational study, data were collected from 28 eyes from 24 subjects with SNIFR. Descriptive statistics were reported, based on the observed anatomico-functional features.

Visual acuity remained stable (median 20/20) in all subjects over a median follow-up of 17 months. All cases demonstrated foveomacular retinoschisis within Henle’s fiber layer, at the junction of the outer plexiform and outer nuclear layers. This schisis cavity extended beyond the limits of the macular OCT temporally in all eyes. In the majority of affected eyes, there were documented features of peripheral retinoschisis and broad attachment of the posterior hyaloid at the macula. Functional testing in a cross-sectional subset demonstrated normal retinal sensitivity centrally but an absolute scotoma peripherally.

Stellate nonhereditary idiopathic foveomacular retinoschisis appears to be associated with peripheral retinoschisis and anomalous or incomplete posterior hyaloid detachment. Despite chronic manifestation, this does not significantly affect central visual function, but can manifest with profound loss of peripheral visual function.

Stellate nonhereditary idiopathic foveomacular retinoschisis appears to be associated with peripheral retinoschisis and anomalous or incomplete posterior hyaloid detachment. Despite chronic manifestation, this does not significantly affect central visual function, but can manifest with profound loss of peripheral visual function.

Atopic dermatitis (AD) is a chronic, inflammatory skin disease associated with itch, sleep disturbance, psychosocial distress, anxiety, and depression.

We aimed to understand the association between AD and aberrant childhood behaviors.

We used data from the Fragile Families and Child Wellbeing Study, a longitudinal birth cohort study of 4898 urban children.

Atopic dermatitis was associated with the 75th or greater percentile of mean behavioral scores at 5 years (multivariable logistic regression; adjusted odds ratio [aOR] [95% confidence interval 95% CI] = 1.51 [1.18-1.93]), 9 years (1.62 [1.32-1.99]), and 15 years (1.44 [1.17-1.76]). There were significantly increased behavioral problems at age of 15 years when AD persisted at ages of 5, 9, and 15 years (Poisson regression; adjusted risk ratio [95% CI] = 1.17 [1.01-1.35]). Atopic dermatitis was associated with 12 aberrant behaviors, particularly fighting (repeated-measures logistic regression; aOR [95% CI] = 1.40 [1.15-1.70]), physically attacking people (1.38 [1.09-1.76]), being sullen (1.31 [1.15-1.49]), worrying (1.41 [1.23-1.61]), and threatening others (1.35 [1.08-1.70]). HG-9-91-01 datasheet Significant 2-way interactions were present between AD and sleep as predictors of underactivity (4.31 [3.06-6.08]), being threatening (aOR [95% CI] = 3.42 [2.20-5.34]), being sullen (3.86 [2.74-5.43]), and nervousness (4.56 [3.29-6.32]).

Childhood AD, particularly persistent disease with sleep disturbances, was associated with a wide range of behavioral problems in childhood and adolescence.

Childhood AD, particularly persistent disease with sleep disturbances, was associated with a wide range of behavioral problems in childhood and adolescence.