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Diffuse ground-glass opacification and poorly defined ground-glass centrilobular nodules were seen on high-resolution computed tomography in one patient and three patients, respectively. All patients were suspected of having idiopathic pulmonary hemosiderosis or interstitial lung disease at other hospitals. All of them received treatment with corticosteroid before admission, but the symptoms did not improve. Moreover, all patients carried compound heterozygous mutations (c.80A>G, c.609G>A) in MMACHC and improved significantly after being treated for cblC deficiency and PAH. CONCLUSIONS CblC deficiency should be considered in the differential diagnosis of DAH especially with PAH, and pulmonary microangiopathy be the main reason of DLD in these patients. © 2020 Wiley Periodicals, Inc.Electrocatalytic water splitting to produce hydrogen and oxygen is regarded as one of the most promising methods to generate clean and sustainable energy for replacing fossil fuels. However, the design and development of an efficient bifunctional catalyst for simultaneous generation of hydrogen and oxygen remains extremely challenging, yet is critical for the practical implementation of water electrolysis. Here, we report a facile method to fabricate novel N-doped carbon nanotube frameworks (NCNTFs) by the pyrolysis of a bimetallic metal organic framework (MIL-88-Fe/Co). The resultant electrocatalyst, Co 3 Fe 7 @NCNTFs, exhibits excellent oxygen evolution reaction (OER) activity, achieving 10 mA/cm 2 at a low overpotential of just 264 mV in 1M KOH solution, and 197 mV for the hydrogen evolution reaction. The high electrocatalytic activity arises from the synergistic effect between the chemistry of the Co 3 Fe 7 and the NCNTs coupled to the novel framework structures. The remarkable electrocatalytic performance of our bifunctional electrocatalyst provides a promising pathway to highly performance overall water splitting and electrochemical energy devices. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.INTRODUCTION Several antiretroviral drugs are being considered for the treatment of COVID-19, the disease caused by a newly identified coronavirus, (SARS-CoV-2). We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. METHODS Three databases were screened from inception to 30 March 2020 for studies reporting clinical outcomes of patients with SARS, MERS or COVID-19 treated with antiretrovirals. RESULTS From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. Of the 21 observational studies reporting treatment outcomes, there were three studies among patients with SARS, six studies among patients with MERS and 12 studies among patients with COVID-19. In one randomized trial 99 patients with severe COVID-19 illness were randomized to receive LPV/r (400/100 mquiring COVID-19. © 2020 World Health Organization; licensed by by John Wiley & Sons Ltd on behalf of the International AIDS Society.Malnutrition contributes to direct and indirect causes of maternal mortality, which is particularly high in Afghanistan. Women’s nutritional status before, during, and after pregnancy affects their own well-being and mortality risk and their children’s health outcomes. Though maternal nutrition interventions have documented positive impact on select child health outcomes, there are limited data regarding the effects of maternal nutrition interventions on maternal health outcomes globally. This scoping review maps policies, data, and interventions aiming to address poor maternal nutrition outcomes in Afghanistan. We used broad search categories and approaches including database and website searches, hand searches of reference lists from relevant articles, policy and programme document requests, and key informant interviews. Inclusion and exclusion criteria were developed by type of source document, such as studies with measures related to maternal nutrition, relevant policies and strategies, and programmatic reasuring maternal nutrition indicators and improving maternal nutrition knowledge and behaviours. © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.OBJECTIVE To assess the relationships between MRI volumetry and [18 F]flortaucipir PET of typical and atypical clinical phenotypes of Alzheimer’s disease, by genarian (age by decade). METHODS Five-hundred and sixty-four participants including those with typical (n = 86) or atypical (n = 80) Alzheimer’s dementia and normal controls (n = 398) underwent apolipoprotein E genotyping, MRI, flortaucipir, and 11 C-PiB; all 166 Alzheimer’s participants were beta-amyloid positive and all controls were beta-amyloid negative. Grey matter volume and flortaucipir standard uptake value ratios were calculated for hippocampus, entorhinal cortex, and neocortex. Ratios of hippocampal-to-neocortical and entorhinal-to-neocortical volume and flortaucipir uptake were also calculated. Linear regression models assessed relationships among regional volume, flortaucipir uptake, and ratios and phenotypes, within three genarians (50-59, 60-69, and 70+). Voxel-level analyses were also performed. RESULTS For 50-59 greater medial temporal atrophy and flortaucipir uptake was observed in the typical compared with atypical phenotype. The typical phenotype also showed greater frontal neocortex uptake with the voxel-level analysis. For 60-69 and 70+ there was greater hippocampal volume loss in the typical compared with atypical phenotype while only the 60-69, but not the 70+ group, showed a difference in hippocampal flortaucipir uptake. find more We also observed a pattern for higher neocortical flortaucipir uptake to correlate with younger age decade for both phenotypes. INTERPRETATION MRI volumetry versus flortaucipir PET relationships differ across Alzheimer’s clinical phenotypes, and also within phenotype across age decades. This suggests that there is potential risk of masked effects by not accounting for genarian in participants with beta-amyloid and tau-positive biomarker defined Alzheimer’s disease. © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.