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MRI data analysis revealed that the classical OT leads to increases in cortical thickness/density of several brain regions, including the right superior and middle frontal gyrus, and bilateral cerebellums. Endocrinology antagonist In addition, the modified OT yielded a lower extent of cortical measures in the right orbital frontal cortex and right insular. Following modified OT, a positive correlation was observed between the odor identification and the right orbital frontal cortex.

Both olfactory training methods can improve olfactory function and that the improvement is associated with changes in the structure of olfactory processing areas of the brain.

Both olfactory training methods can improve olfactory function and that the improvement is associated with changes in the structure of olfactory processing areas of the brain.

Data-driven methods such as independent component analysis (ICA) makes very few assumptions on the data and the relationships of multiple datasets, and hence, are attractive for the fusion of medical imaging data. Two important extensions of ICA for multiset fusion are the joint ICA (jICA) and the multiset canonical correlation analysis and joint ICA (MCCA-jICA) techniques. Both approaches assume identical mixing matrices, emphasizing components that are common across the multiple datasets. However, in general, one would expect to have components that are both common across the datasets and distinct to each dataset.

We propose a general framework, disjoint subspace analysis using ICA (DS-ICA), which identifies and extracts not only the common but also the distinct components across multiple datasets. A key component of the method is the identification of these subspaces and their separation before subsequent analyses, which helps establish better model match and provides flexibility in algorithm and order choice.

We compare DS-ICA with jICA and MCCA-jICA through both simulations and application to multiset functional magnetic resonance imaging (fMRI) task data collected from healthy controls as well as patients with schizophrenia.

The results show DS-ICA estimates more components discriminative between healthy controls and patients than jICA and MCCA-jICA, and with higher discriminatory power showing activation differences in meaningful regions. When applied to a classification framework, components estimated by DS-ICA results in higher classification performance for different dataset combinations than the other two methods.

These results demonstrate that DS-ICA is an effective method for fusion of multiple datasets.

These results demonstrate that DS-ICA is an effective method for fusion of multiple datasets.

Major depressive disorder (MDD) is a prevalent mental illness that is diagnosed through questionnaire-based approaches; however, these methods may not lead to an accurate diagnosis. In this regard, many studies have focused on using electroencephalogram (EEG) signals and machine learning techniques to diagnose MDD.

This paper proposes a machine learning framework for MDD diagnosis, which uses different types of EEG-derived features. The features are extracted using statistical, spectral, wavelet, functional connectivity, and nonlinear analysis methods. The sequential backward feature selection (SBFS) algorithm is also employed to perform feature selection. Various classifier models are utilized to select the best one for the proposed framework.

The proposed method is validated with a public EEG dataset, including the EEG data of 34 MDD patients and 30 healthy subjects. The evaluation of the proposed framework is conducted using 10-fold cross-validation, providing the metrics such as accuracy (AC), sensitivity (SE), specificity (SP), F1-score (F1), and false discovery rate (FDR). The best performance of the proposed method has provided an average AC of 99%, SE of 98.4%, SP of 99.6%, F1 of 98.9%, and FDR of 0.4% using the support vector machine with RBF kernel (RBFSVM) classifier.

The obtained results demonstrate that the proposed method outperforms other approaches for MDD classification based on EEG signals.

According to the obtained results, a highly accurate MDD diagnosis would be provided using the proposed method, while it can be utilized to develop a computer-aided diagnosis (CAD) tool for clinical purposes.

According to the obtained results, a highly accurate MDD diagnosis would be provided using the proposed method, while it can be utilized to develop a computer-aided diagnosis (CAD) tool for clinical purposes.Mechanisms of information transmission using tactile sense are one of major concerns in producing simulated experience in virtual or augmented reality as well as in compensating elderly or impaired people with diminished tactile sensory function. However, important mechanism of the difference of peak latency in the primary somatosensory cortex (SI) between electrical and mechanical stimulations of finger skin is not fully understood. We propose a computational approach to fuse a computational model to simulate temporal and spatial transmission processes from mechanical stimuli to the SI and experimental method using a magnetoencephalograph (MEG). In our model, a tactile model that combined a three-dimensional mechanical model of fingertip skin and a neurophysiological model of a slowly adapting type 1 (SA1) mechanoreceptor was integrated with a somatosensory evoked field (SEF) response model. Electrical and mechanical stimulations were applied to the same locations of the right or left index fingertips of three subjects using a MEG. By identifying parameters of the SEF response model using the electrical stimulation test data, predicted first peak latency due to a mechanical stimulus was identical to its average value obtained from the mechanical stimulation test data, while the spatial map predicted at the multiple SA1 receptors qualitatively corresponded to the MEG image map in the timings of peak latency. This suggests that mechanical change in the skin and neurophysiological responses generate the difference of peak latency in SI between electrical and mechanical stimulations. The computational approach has the potential for detailed investigation of mechanisms of tactile information transmission.