Warner Houston

T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for chimeric antigen receptor T cell (CAR-T cell) technology, by which T cells are redirected in a major…[Read more]

These changes were associated with alterations in pup immunity including increased frequencies and numbers of activated CD4 T cells (CD4+CD44hi) in NbM offspring spleens. CONCLUSIONS Taken together, we show that preconception helminth infections impact offspring immunity possibly through alteration of maternal and offspring microbiota. This…[Read more]

In the phylogenetic reconstruction, based on the mitochondrial cytochrome c oxidase subunit I (COI) gene, the Adriatic taxon results clearly indicate that this is distinct from the other species of the genus and formed a well-supported clade with other Streblospio sp. specimens from India. Nucleotide divergences calculated between the Adriatic…[Read more]

There was no difference in CR (p = 0.90) or time to CR (p = 0.31) between the treatment cohorts. Overall, 22% experienced a disease recurrence. On multivariable analysis, EC histology was the only covariate associated with a decreased Prog response (HR 0.48; p = 0.007). Only 17% of the cohort achieved a live-birth pregnancy, the majority of which…[Read more]

The authors found a yearly incidence of 62 cases of acute limb-threatening upper extremity trauma per 100,000 trauma admissions. CONCLUSIONS Multiple factors influence the surgical decision to perform primary amputation or to attempt a salvage procedure following limb-threatening upper extremity trauma. Knowing which patients will have the most…[Read more]

Deafferentation pain (DP), a typical neuropathic pain, occurs due to peripheral or central sensory nerve injury, which causes abnormal discharge of the upstream neurons or C fibers. Current treatment methods for DP have multiple side effects. Bone marrow mesenchymal stem cells (BMSC) have been used to treat neuropathic pain because of their…[Read more]