Wise Riddle

e further adopted to improve orphan drug availability and reduce the economic burden of rare diseases.

This study showed that patients with PDA had the lowest physical functioning score, while patients with ITP scored the lowest in the emotional functioning, social functioning, school functioning, psychosocial health, and total scores.…[Read more]

Although the theory of green development behavior and performance of industrial enterprises (GDBP-IE) reveals that the green development behavior (GDB) of industrial enterprises is affected by internal and external factors and produces performance, it lacks a clear mechanism. This paper aims to verify the theory of GDBP-IE and reveals the…[Read more]

Phthalate acid esters (PAEs) are environmentally ubiquitous and have aroused a worldwide concern due to their threats to environment and human health. Di-n-butyl phthalate (DBP) is one of the most frequently observed PAEs in the environment. In this study, a novel bacterium identified as Pseudomonas sp. YJB6 that isolated from PAEs-contaminated…[Read more]

HuR is overexpressed in gliomas and is associated with poor prognosis and treatment resistance. Our review provides a link between the HuR role in the regulation of cell fusion and tunneling nanotube formations in the glioma microenvironment and the potential suppression of these processes by different classes of HuR inhibitors.Elytrigia atherica…[Read more]

Cell cycle analysis unveiled the G0/G1 phase inhibition and wound healing assay inferred the inhibition of in vitro cell migration by compound 12c in lung cancer cells. Remarkably, the safety profile of compound 12c was disclosed by screening against normal human lung epithelial cell line (BEAS-2B IC50 71.2 ± 7.95 μM) with a selectivity index r…[Read more]

These results suggest that expression of the cartilage matrix genes is controlled by an incoherent feedforward loop via Sox9 and ERK, which is supported by a mathematical model. Furthermore, the modeling analysis suggests that a Sox9-ERK incoherent feedforward regulation augments the robustness against the variation of upstream factors. The…[Read more]

AT2 can promote the growth and proliferation and suppress the apoptosis of CRC cells. The changes in lncRNA CCAT2 expression are associated with poor prognosis.

Laparoscopic complete mesorectal excision (CME) can be used for the treatment of colon cancer. This study was designed to assess short-term and long-term outcomes of laparoscopic CME…[Read more]