Hein Hood

Ultimately, we discovered a novel TLR3 agonist, TL-532, demonstrating promising anticancer properties.

The interplay between autophagy, cellular environment, and cell type dictates the direction of cell death (promotion or inhibition). Genetic involvement of Atg1 in the regulation of Pmk1 MAPK in fission yeast was suggested by our prior…[Read more]

Neurotransmitter and neuropeptide cues within the tumor microenvironment (TME) induce alterations in immune cell phenotypes, specifically, heightened exhaustion and decreased effector activity, facilitating immune evasion and tumor advancement. Two categories of immune regulation by nerves associated with tumors are highlighted in this review:…[Read more]