Activity

org/page/journal/pubdates for revised estimates.

Myocarditis is one of the most common causes leading to heart failure in children and a possible genetic background has been postulated. We sought to characterize the clinical and genetic characteristics in patients with myocarditis ≤18 years of age to predict outcome.

A cohort of 42 patients (Genetics in Pediatric Myocarditis) with biopsy-proven myocarditis underwent genetic testing with targeted panel sequencing of cardiomyopathy-associated genes. Genetics in Pediatric Myocarditis patients were divided into subgroups according to the phenotype of dilated cardiomyopathy (DCM) at presentation, resulting in 22 patients without DCM (myocarditis without phenotype of DCM) and 20 patients with DCM (myocarditis with phenotype of DCM).

Myocarditis with phenotype of DCM patients (median age 1.4 years) were younger than myocarditis without phenotype of DCM patients (median age 16.1 years;

<0.001) and were corresponding to heart failure-like and coronary syndrome-like phenotypes, respectively. At least one lewly diagnosed with myocarditis and DCM phenotype is warranted.

We report heterozygous likely pathogenic/pathogenic variants in biopsy-proven pediatric myocarditis. Myocarditis patients with DCM phenotype were characterized by early-onset heart failure, significant enrichment of likely pathogenic/pathogenic variants, and poor outcome. These phenotype-specific and age group-specific findings will be useful for personalized management of these patients. Genetic evaluation in children newly diagnosed with myocarditis and DCM phenotype is warranted.Purpose The aim of this study was to extract key learning from intervention studies in which qualitative aspects of dosage, dose form, have been examined for children with developmental language disorder (DLD)-in vocabulary, morphosyntax, and phonology domains. This research paper emerged from a pair of systematic reviews, aiming to synthesize available evidence regarding qualitative and quantitative aspects of dosage. While quantitative aspects had been experimentally manipulated, the available evidence for dose form (tasks or activities within which teaching episodes are delivered) was less definitive. Despite this, the review uncovered insights of value to DLD research. SAGagonist Method A preregistered systematic review (PROSPERO ID CRD42017076663) adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was completed. Included papers were quasi-experimental, randomized controlled trial, or cohort analytic studies, published in any language between January 2006 and May 2019; pathology research would benefit from an agreed taxonomy of dose form components and standardized reporting of intervention studies, to enable cross-study comparisons and a systematic accrual of knowledge to identify optimal dose form for clinical application.This corrects the article DOI 10.1103/PhysRevLett.125.051101.In equilibrium liquid crystals, chirality leads to a variety of spectacular three-dimensional structures, but chiral and achiral phases with the same broken continuous symmetries have identical long-time, large-scale dynamics. In this Letter, starting from active model H^*, the general hydrodynamics of a pseudoscalar in a momentum-conserving fluid, we demonstrate that chirality qualitatively modifies the dynamics of layered liquid crystals in active systems in both two and three dimensions due to an active “odder” elasticity. In three dimensions, we demonstrate that the hydrodynamics of active cholesterics differs fundamentally from smectic-A liquid crystals, unlike their equilibrium counterpart. This distinction can be used to engineer a columnar array of vortices, with an antiferromagnetic vorticity alignment, that can be switched on and off by external strain. A two-dimensional chiral layered state-an array of lines on an incompressible, freestanding film of chiral active fluid with a preferred normal direction-is generically unstable. However, this instability can be tuned in easily realizable experimental settings when the film is either on a substrate or in an ambient fluid.Time-periodic driving facilitates a wealth of novel quantum states and quantum engineering. The interplay of Floquet states and strong interactions is particularly intriguing, which we study using time-periodic fields in a one-dimensional quantum gas, modeled by a Luttinger liquid with periodically changing interactions. By developing a time-periodic operator algebra, we are able to solve and analyze the complete set of nonequilibrium steady states in terms of a Floquet-Bogoliubov ansatz and known analytic functions. Complex valued Floquet eigenenergies occur when integer multiples of the driving frequency approximately match twice the dispersion energy, which correspond to resonant states. In experimental systems of Lieb-Liniger bosons we predict a change from power-law correlations to dominant collective density wave excitations at the corresponding wave numbers as the frequency is lowered below a characteristic cutoff.Using combined data from the Relativistic Heavy Ion and Large Hadron Colliders, we constrain the shear and bulk viscosities of quark-gluon plasma (QGP) at temperatures of ∼150-350  MeV. We use Bayesian inference to translate experimental and theoretical uncertainties into probabilistic constraints for the viscosities. With Bayesian model averaging we propagate an estimate of the model uncertainty generated by the transition from hydrodynamics to hadron transport in the plasma’s final evolution stage, providing the most reliable phenomenological constraints to date on the QGP viscosities.Mechanisms-collections of rigid elements coupled by perfect hinges which exhibit a zero-energy motion-motivate the design of a variety of mechanical metamaterials. We enlarge this design space by considering pseudo-mechanisms, collections of elastically coupled elements that exhibit motions with very low energy costs. We show that their geometric design generally is distinct from those of true mechanisms, thus opening up a large and virtually unexplored design space. We further extend this space by designing building blocks with bistable and tristable energy landscapes, realize these by 3D printing, and show how these form unit cells for multistable metamaterials.