Activity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has been a global pandemic. Researchers have made great efforts to investigate SARS-CoV-2. However, there are few studies analyzing the general situation of SARS-CoV-2 research at global level. This study aimed to characterize global scientific efforts based on SARS-CoV-2 publications.

SARS-CoV-2 -related publications were retrieved using Web of Science. The number of publications, citation, country, journal, study topic, total confirmed cases, and total deaths were analyzed.

A total of 441 publications were identified. China contributed the largest number of publications (198, 44.90%), followed by USA (51, 11.56%), Italy (28, 6.35%), Germany (19, 4.31%), and South Korea (13, 2.95%). Upper-middle-income economies (51.70%) produced the most SARS-CoV-2 publications, followed by high-income (45.12%), lower-middle-income (2.95%), and low-income economies (0.23%). The research output had a significant correlations with total confirmed caseput in the field of SARS-CoV-2. China was the most prolific country, and had the highest quality of publications on SARS-CoV-2.The rapid emergence of bacterial resistance worldwide is a serious problem, leading to many therapeutic failures and rendering inactive effective antibiotics currently used . This problem has recently been accelerated by conflicts and its related migration. The antibiotic resistance phenomenon is diffused in Syria with a high rate of multi drug resistance cases in gram negative and gram positive organisms during and after the Syrian crisis as a result of misprescribing and overprescribing of antibiotics. The inappropriate use of antibiotic plays an important role in resistance generation. Hence, big efforts are urgently needed by using phenotypic and genetic analysis of bacterial strains against antibiotics to increase characterization and identification of mutant resistant strains and find new strategies to control the spread of antimicrobial resistance infections. This review highlights the antibacterial resistance problem in Syria, showing its negative impact and presenting a sum of efforts that are urgently needed to overcome this problem.Targeted lipid nanobubbles as theranostic ultrasound molecular probes with both targeted contrast-enhanced ultrasound molecular imaging and synergistic treatment capabilities are expected to overcome severe challenges in the diagnosis and treatment of refractory triple-negative breast cancer (TNBC). In this study, AS1411 aptamer-functionalised nucleolin-targeted doxorubicin-loaded lipid nanobubbles (AS1411-DOX-NBs) were constructed, and their physicochemical properties as well as anti-tumour and cardioprotective efficacies were systematically tested and evaluated. The results showed that AS1411-DOX-NBs can carry and maintain the physicochemical and pharmacodynamic properties of doxorubicin (DOX) and show stronger tumour cell-killing ability in vitro by increasing the active uptake of drugs. AS1411-DOX-NBs also significantly inhibited the growth of TNBC xenografts while maintaining the weight and health of the mice. Echocardiography and pathological examination further confirmed that AS1411-DOX-NBs effectively caused tumour tissue apoptosis and necrosis while reducing DOX-induced cardiotoxicity. The AS1411-DOX-NBs constructed in this study enable both targeted contrast-enhanced ultrasound molecular imaging and synergistic therapeutic efficacy and can be used as safe and efficient theranostic ultrasound molecular probes for the diagnosis and treatment of TNBC.Herein, first-principles calculations were employed to study the electronic, topological, and superconducting properties of InTaX2(X = S, Se). InTaX2exhibits nodal lines in the absence of spin-orbit coupling (SOC); on SOC inclusion, the nodal lines form Weyl rings with the Weyl points classified as a type-II Weyl semimetal (WSM) with tilted cones. Using Green functions method calculations, surface states distinguishable from the bulk states, and Fermi arcs surface states were visualized on the (001) easily cleavable indium terminated surface of both materials. The electron-phonon calculations using the Allen-Dynes relations predict InTaSe2and InTaS2to be superconducting around 2.38 K and 3.25 K. The prediction of these exotic properties in InTaX2(X = S, Se) makes them suitable for experimental validation of topological superconductivity in type-II WSMs.In the Hamiltonian adaptive resolution simulation method (H-AdResS) it is possible to simulate coexisting atomistic (AT) and ideal gas representations of a physical system that belong to different subdomains within the simulation box. The Hamiltonian includes a field that bridges both models by smoothly switching on (off) the intermolecular potential as particles enter (leave) the AT region. In practice, external one-body forces are calculated and applied to enforce a reference density throughout the simulation box, and the resulting external potential adds up to the Hamiltonian. This procedure suggests an apparent dependence of the final Hamiltonian on the system’s thermodynamic state that challenges the method’s statistical mechanics consistency. selleck chemicals llc In this paper, we explicitly include an external potential that depends on the switching function. Hence, we build a grand canonical potential for this inhomogeneous system to find the equivalence between H-AdResS and density functional theory (DFT). We thus verify that the external potential inducing a constant density profile is equal to the system’s excess chemical potential. Given DFT’s one-to-one correspondence between external potential and equilibrium density, we find that a Hamiltonian description of the system is compatible with the numerical implementation based on enforcing the reference density across the simulation box. In the second part of the manuscript, we focus on assessing our approach’s convergence and computing efficiency concerning various model parameters, including sample size and solute concentrations. To this aim, we compute the excess chemical potential of water, aqueous urea solutions and Lennard-Jones (LJ) mixtures. The results’ convergence and accuracy are convincing in all cases, thus emphasising the method’s robustness and capabilities.