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Molina Vogel posted an update 2 months, 2 weeks ago
When somatropin is started, it may be required to modify the dosage of antidiabetic drugs. Chronic somatropin overdose may result in glucose intolerance or acromegaly. Patients should be watched for signs of glucose intolerance since somatropin may decrease insulin sensitivity, especially at larger dosages. Obesity (including obesity in Prader-Willi syndrome individuals), Turner syndrome, or a family history of type II diabetes are risk factors for glucose intolerance.
Funduscopic examination of patients is recommended upon initiation of therapy and periodically throughout treatment. If treatment with somatropin is initiated, these patients should be carefully monitored for development of neoplasms. Because children with certain rare genetic causes of short stature have an increased risk of developing malignancies, consider the risks and benefits of starting somatropin in these patients. Girls with Turner syndrome may have an even greater risk of developing pancreatitis compared to others undergoing somatropin treatment. Pancreatitis has been rarely reported in adults and children receiving somatropin, with pediatric patients appearing to be at greater risk compared to adults.
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