Hay Wilcox

A randomized, double-blind, placebo-controlled phase 2 trial of the HPV16/18 vaccine encompassed healthy Chinese females, categorized into three age groups (9-17 years, 18-26 years, 27-45 years). These comprised 600, 240, and 360 participants, respectively, and were randomized to receive three doses of the vaccine or placebo, over a time frame of…[Read more]

The immunosuppressive tumor microenvironment is created by tumors through both changes in protein expression and modifications to glycosylation, such as alterations in sialoglycan levels. Siglec immune receptors have a specific affinity for sialoglycans that display sialic acid sugar residues. Cancer cells leverage Siglec-7, an inhibitory immune…[Read more]

In contrast, the concurrent development of adverse drug reactions (namely gastrointestinal, renal, hepatic, and cardiovascular) and drug interactions emphasized the necessity of prescribing the optimal NSAID for each patient’s specific requirements. In this narrative review, we detail the function of nonsteroidal anti-inflammatory drugs (NSAIDs),…[Read more]