Albright Tan

05). Age, organs and nerve invasion were independent risk factors for impaired fasting glucose. Low high-density lipoprotein (HDL) was also a risk factor for incident of DM (OR = 0.15, 95%CI 0.03-0.66). G2/G3 was an independent risk factor for DM in women.

Our data shows that the prevalence of DM is 17.26% in patients with PNENs and is…[Read more]

By using the learned spatial and spectral low-rank structures, we formulate the proposed HSI super-resolution model as a variational optimization problem, which can be readily solved by the ADMM algorithm. Compared with state-of-the-art hyperspectral super-resolution methods, the proposed method shows better performance on three benchmark datasets…[Read more]

Proteolysis targeting chimeras (PROTACs) induce intracellular degradation of target proteins. Their bifunctional structure puts degraders in a chemical space where ADME properties often complicate drug discovery. Herein we provide the first structural insight into PROTAC cell permeability obtained by NMR studies of a VHL-based PROTAC (1), which is…[Read more]

In vivo study showed that lenvatinib attenuated liver fibrosis development with reduction in activated hepatic stellate cells and mRNA expression of profibrogenic markers. Intrahepatic neovascularization was ameliorated with reduced hepatic expressions of Vegf1, Vegf2 and Vegfa in lenvatinib-treated rats. Collectively, these results suggest the…[Read more]

saprophyticus and identifies putative new virulence factors.GeneXpert-based testing with Xpert MTB/RIF or Ultra assays is essential for tuberculosis diagnosis. However, testing may be affected by cartridge and staff shortages. More efficient testing strategies could help, especially during the coronavirus disease pandemic. We searched the…[Read more]

We then measured the selectivity of this sustained response by presenting F1 and F2 to different electrodes and at different between-electrode distances. This revealed a broad tuning that, we argue, reflects the overlap between the excitation elicited by the two electrodes. Our results also provide a glimpse of the neural nonlinearity in the…[Read more]

Cytochrome P450 2C9 (CYP2C9) is involved in the metabolism of cancer drugs and exogenous carcinogens. In our study, CYP2C9 was downregulated in multiple cohorts of human esophageal squamous cell carcinoma (ESCC). Until now, its role and epigenetic regulation of CYP2C9 repression in ESCC remain poorly understood. CYP2C9 repression in collected ESCC…[Read more]

The virtue of compassion is a valid antidote to lighten the burden of negative effects brought by the COVID-19 pandemic. However, real-life situations can attest that this is not always the kind of behavior for some people since the current situation is considered as ‘survival of the fittest.’ In its absence, the respect of freedom by public…[Read more]

Regorafenib has been approved among the treatment options for patients with advanced stage colorectal cancer (CRC), hepatocellular carcinoma (HCC), and gastrointestinal stromal tumors (GIST). In this study, we aim to report the real-life experience of the safety and tolerability regorafenib in our institution.

We conducted a retrospective…[Read more]