Kirby Farrell

Finally, depletion of PPARg or CPT1 restores quiescence in these mutant HSCs under inflammatory stress. Our results suggest that this novel FANCD2/HES1/PPARƔ axis may constitute a key component of immunometabolic regulation, connecting inflammation, cellular metabolism and HSC function.

Cutaneous mucormycosis is an emerging opportunistic…[Read more]

Family caregivers play a curial role in supporting and caring for their mentally ill relatives. Their struggle for facing stigma and shouldering caregiving burden is marginalized, undervalued, and invisible to medical services. This study assessed the stigma and burden of mental illnesses, and their correlates among family caregivers of mentally…[Read more]

The Dup15q group was the only condition with significantly increased UBE3A mRNA levels when compared to the control group (p  less then  0.001). Both the AS and Dup15q groups also had significantly elevated SNORD116 mRNA levels compared to controls (AS p  less then  0.0001; Dup15q p = 0.002). Both UBE3A and SNORD116 mRNA levels were positively…[Read more]

The diffusion rate of a water droplet on the PVDF/CFO membrane surface is reduced from 0.23 to 0.05 cm2/s by covering the membrane surface with PM. Consequently, the PM capturing efficiency is dramatically improved up to 175% from ME membranes with the poling process and applying a magnetic field. Furthermore, the PM was successfully captured on…[Read more]

obesity. Conclusion This study illustrated the high prevalence of socio-behavioral-metabolic risk factors for CDL, and identified similarities and distinct differences in the risk profiles of rural and urban communities. Considering the CDL risk profiles of communities can assist in prioritizing health needs and contribute to the development of…[Read more]

8%; center-level range 0.9-3.8%) of included patients (median age 55 (IQR 34-76), 84% Caucasian, 60% male, 92% blunt, median ISS 9 (IQR5-16)). Death after CC occurred in 982/5,097 patients for an FTR-C rate of 19.3% (center-level range 7.8-30.4%). 10/27 centers were high-performers (95% confidence interval for OE ratio less then 1) for CC and 2/27…[Read more]