Berntsen Herndon

However, when corticosteroids intervened the LPS-primed macrophages, it also negatively regulated NLRP3-inflammasome activation through suppressing mitochondrial reactive oxygen species (mtROS) production. Our results revealed that corticosteroids played a protection role in LPS-induced inflammation and ALI by suppressing both NF-κB signal…[Read more]

The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and cardiovascular events in the FOURIER randomized clinical trial. Patients with metabolic syndrome (MetS) are at increased cardiovascular risk.

To investigate outcomes with evolocumab in patients with and without MetS.

The FOURIER trial randomized patients…[Read more]

We demonstrate luminescent solar concentrators (LSCs) based on colloidal silicon quantum dots (SiQDs) as UV-selective fluorophores and coupled with front-facing silicon photovoltaic cells for the solar window application. The visibly transparent LSC composed of a thin layer of liquid SiQD suspension sandwiched between two thin glass slabs…[Read more]

Participants with a work rate difference between POE and AT (82% of all participants) were not different regarding breathing patterns of breathing frequency and tidal volume. However, the difference in work rate was explained by an early increase in ventilation and a higher aerobic capacity.The Igfn1 gene produces multiple proteins by alternative…[Read more]

asingly common within medical schools, this understanding may be important for leaders in academic medicine considering potential indirect benefits of this educational model.

There still remains agap between those who conduct science and those who engage in educating others about health sciences through various forms of social media. Few…[Read more]

Marine ancestors of freshwater sponges had to undergo a series of physiological adaptations to colonize harsh and heterogeneous limnic environments. Besides reduced salinity, river-lake systems also have calcium concentrations far lower than seawater. Cell adhesion in sponges is mediated by calcium-dependent multivalent self-interactions of…[Read more]

Functional deficits of the forehead and midface can pose significant problems for patients varying from mild asymmetry to various degrees of functional impairment including total paralysis. Our objectives were to analyse the use of bio-absorbable implants to reconstruct forehead and midface deficits, all of which were for functional (noncosmetic)…[Read more]